Waranun Buajeeb

The relationship of recurrent aphthous stomatitis (RAS) to psychological factors has been reported. The purpose of this study was to determine anxiety in RAS patients. All new patients seen during May 1988-November 1988 at the Oral Diagnosis Clinic, Department of Oral Medicine, Faculty of Dentistry, Mahidol University, completed a questionnaire regarding their history of RAS. For the measurement of anxiety, patients were given the Self-rating Anxiety Scale (SAS). Of the 3,106 patients studied, 46.7% reported a positive history of RAS. In this population, females were significantly (P less than 0.001) more anxious than males. The mean SAS score obtained from patients with RAS was significantly (P less than 0.001) higher than that of patients without RAS in each sex. It is concluded that patients with RAS are more anxious than patients without RAS.

The purpose of this study was to compare the efficacy of retinoic acid in an oral base 0.05% with fluocinolone acetonide in an oral base 0.1% in the treatment of atrophic and erosive oral lichen planus. Thirty-three patients with histologically proven oral lichen planus were asked to participate in the study. Lesions were scored ranging from 0 (no lesion) to 5 (large erosion) according to the severity. Patients were randomly assigned to receive either topical fluocinolone acetonide or topical retinoic acid. They were instructed to apply the medication on dried lesions four times a day. The lesions were evaluated after 2 and 4 weeks of treatment. The sign scores were analyzed by the Wilcoxon rank sum test. Eighteen patients receiving topical fluocinolone acetonide improved from the average score of 3.0 to 1.5 after 4 weeks of treatment, whereas 15 patients receiving topical retinoic acid showed little change (average score, 2.9 and 2.4, respectively). The changes were statistically significantly different between the two groups (p = 0.01). The results suggest that 0.1% fluocinolone acetonide reduced the severity of atrophic and erosive oral lichen planus better than 0.05% retinoic acid.

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