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Identification of KCC2 Mutations in Human Epilepsy Suggests Strategies for Therapeutic Transporter Modulation
Frontiers
Epilepsy is a common neurological disorder characterized by recurrent and unprovoked seizures thought to arise from impaired balance between neuronal...
6 months ago
Dexterous Manipulation for Multi-Fingered Robotic Hands With Reinforcement Learning: A Review
Frontiers
Our purpose is to present a comprehensive review of the techniques for dexterous manipulation with multi-fingered robotic hands.
6 months ago
Anion transport and GABA signaling
Frontiers
Whereas activation of GABAA receptors by GABA usually results in a hyperpolarizing influx of chloride into the neuron, the reversed chloride driving force...
6 months ago
Role of NKCC1 and KCC2 in Epilepsy: From Expression to Function
Frontiers
As a main inhibitory neurotransmitter in the central nervous system, γ-aminobutyric acid (GABA) activates chloride-permeable GABAa receptors (GABAa Rs) and...
11 months ago
A novel pathogenic SLC12A5 missense variant in epilepsy of infancy with migrating focal seizures causes impaired KCC2 chloride extrusion
Frontiers
The potassium-chloride co-transporter 2, KCC2, is a neuron-specific ion transporter that plays a multifunctional role in neuronal development.
6 months ago
Neto2-null mice have impaired GABAergic inhibition and are susceptible to seizures
Frontiers
Neto2 is a transmembrane protein that interacts with the neuron-specific K+-Cl− cotransporter (KCC2) in the central nervous system (CNS).
6 months ago
Regulatory domain or CpG site variation in SLC12A5, encoding the chloride transporter KCC2, in human autism and schizophrenia
Frontiers
Many encoded gene products responsible for neurodevelopmental disorders (NDs) like autism spectrum disorders (ASD), schizophrenia (SCZ),...
6 months ago
Local genetic adaptation to habitat in wild chimpanzees
Science | AAAS
How populations adapt to their environment is a fundamental question in biology. Yet, we know surprisingly little about this process,...
1 week ago
Severe inflammation in new-borns induces long-term cognitive impairment by activation of IL-1β/KCC2 signaling during early development
BMC Medicine
Neonatal sepsis can induce long-term cognitive impairment in adolescence or adulthood, but the underlying molecular mechanism is not fully...
29 months ago
Disruption of Slc4a10 augments neuronal excitability and modulates synaptic short-term plasticity
Frontiers
Slc4a10 is a Na+-coupled Cl−-HCO3− exchanger, which is expressed in principal and inhibitory neurons as well as in choroid plexus epithelial...
115 months ago