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On the nature based flood defence dilemma and its Resolution: A game theory based analysis

ScienceDirect.com
We have looked into the complexities of nature-based flood defence implementation and its resolutions, modelling decision-making situations using game theory.
57 months ago

A novel pathogenic SLC12A5 missense variant in epilepsy of infancy with migrating focal seizures causes impaired KCC2 chloride extrusion

Frontiers
The potassium-chloride co-transporter 2, KCC2, is a neuron-specific ion transporter that plays a multifunctional role in neuronal development.
5 months ago

Anion transport and GABA signaling

Frontiers
Whereas activation of GABAA receptors by GABA usually results in a hyperpolarizing influx of chloride into the neuron, the reversed chloride driving force...
5 months ago

Neto2-null mice have impaired GABAergic inhibition and are susceptible to seizures

Frontiers
Neto2 is a transmembrane protein that interacts with the neuron-specific K+-Cl− cotransporter (KCC2) in the central nervous system (CNS).
5 months ago

Role of NKCC1 and KCC2 in Epilepsy: From Expression to Function

Frontiers
As a main inhibitory neurotransmitter in the central nervous system, γ-aminobutyric acid (GABA) activates chloride-permeable GABAa receptors (GABAa Rs) and...
9 months ago

Population connectivity shapes the distribution and complexity of chimpanzee cumulative culture

Science | AAAS
Although cumulative culture is a hallmark of hominin evolution, its origins can be traced back to our common ancestor with chimpanzees.
2 weeks ago

Disruption of Slc4a10 augments neuronal excitability and modulates synaptic short-term plasticity

Frontiers
Slc4a10 is a Na+-coupled Cl−-HCO3− exchanger, which is expressed in principal and inhibitory neurons as well as in choroid plexus epithelial...
113 months ago

Role of the neuronal K-Cl co-transporter KCC2 in inhibitory and excitatory neurotransmission

Frontiers
The K-Cl co-transporter KCC2 plays multiple roles in the physiology of central neurons and alterations of its function and/or expression are associated with...
5 months ago

Severe inflammation in new-borns induces long-term cognitive impairment by activation of IL-1β/KCC2 signaling during early development

BMC Medicine
Neonatal sepsis can induce long-term cognitive impairment in adolescence or adulthood, but the underlying molecular mechanism is not fully...
28 months ago

Current view on the functional regulation of the neuronal K+-Cl− cotransporter KCC2

Frontiers
In the mammalian central nervous system (CNS), the inhibitory strength of chloride (Cl−)-permeable GABAA and glycine receptors (GABAAR and GlyR) depends on...
5 months ago