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Five weeks of dynamic finger flexor strength training on bouldering performance and climbing-specific strength tests. A randomized controlled trial

Frontiers
The aim of the study was to examine the effects of a 5-week dynamic finger flexor strength training program on bouldering performance and climbing-specific...
1 month ago

Population connectivity shapes the distribution and complexity of chimpanzee cumulative culture

Science | AAAS
Although cumulative culture is a hallmark of hominin evolution, its origins can be traced back to our common ancestor with chimpanzees.
2 weeks ago

Modeling acute myocardial infarction and cardiac fibrosis using human induced pluripotent stem cell-derived multi-cellular heart organoids

Nature
Heart disease involves irreversible myocardial injury that leads to high morbidity and mortality rates. Numerous cell-based cardiac in vitro models have...
7 months ago

Early establishment of chloride homeostasis in CRH neurons is altered by prenatal stress leading to fetal HPA axis dysregulation

Frontiers
Corticotropin-releasing hormone (CRH) neurons play an important role in the regulation of neuroendocrine responses to stress. The excitability of CRH...
8 months ago

Power Analysis: Gravel Worlds never let up

Escape Collective
Mathieu van der Poel may have relinquished his rainbow bands on the roads of Zurich to a defiant Tadej Pogačar, however only one week later the 2023 Road...
1 month ago

Developmental loss of NMDA receptors results in supernumerary forebrain neurons through delayed maturation of transit-amplifying neuroblasts | Scientific Reports

Nature
We find that these fish have a progressive supernumerary neuron phenotype confined to the telencephalon at the end of embryonic neurogenesis.
9 months ago

A novel pathogenic SLC12A5 missense variant in epilepsy of infancy with migrating focal seizures causes impaired KCC2 chloride extrusion

Frontiers
The potassium-chloride co-transporter 2, KCC2, is a neuron-specific ion transporter that plays a multifunctional role in neuronal development.
5 months ago

Serine 937 phosphorylation enhances KCC2 activity and strengthens synaptic inhibition

Nature
The potassium chloride cotransporter KCC2 is crucial for Cl- extrusion from mature neurons and thus key to hyperpolarizing inhibition.
11 months ago

Region and layer-specific expression of GABAA receptor isoforms and KCC2 in developing cortex

Frontiers
Introductionγ-Aminobutyric acid (GABA) type A receptors (GABAARs) are ligand-gated Cl-channels that mediate the bulk of inhibitory neurotransmission in the...
5 months ago

Skin-to-skin transfer from the delivery room to the neonatal unit for neonates of 1,500g or above: a feasibility and safety study

Frontiers
ObjectiveImmediate skin-to-skin contact (SSC) is already standard care for healthy term newborns, but its use for term or preterm newborns requiring...
5 months ago