During the two centuries following European contact, the world of late prehistoric Mississippian chiefdoms collapsed and Native communities there fragmented, migrated, coalesced, and reorganized into new and often quite different societies. Shuck-Hall, argue that such a period and region of instability and regrouping constituted a “shatter zone.” In this anthology, archaeologists, ethnohistorians, and anthropologists analyze the shatter zone created in the colonial South by examining the interactions of American Indians and European colonists. The forces that destabilized the region included especially the frenzied commercial traffic in Indian slaves conducted by both Europeans and Indians, which decimated several southern Native communities; the inherently fluid political and social organization of precontact Mississippian chiefdoms; and the widespread epidemics that spread across the South. Using examples from a range of Indian communities—Muskogee, Catawba, Iroquois, Alabama, Coushatta, Shawnee, Choctaw, Westo, and Natchez—the contributors assess the shatter zone region as a whole, and the varied ways in which Native peoples wrestled with an increasingly unstable world and worked to reestablish order.